Multimodal Quantification of white matter in CN, AD, FTD, LBD Lead Investigator: Alberto Redolfi Institution : IRCCS Centro San Giovanni di Dio Fatebenefratelli E-Mail : aredolfi@fatebenefratelli.eu Proposal ID : 1630 Proposal Description: The data requested will be used to train an advanced machine learning tool called MUQUBIA (in Italian, MUltimodale QUantificazione sostanza BIAnca - in English, Multimodal Quantification of white matter), aiming at improving the differential diagnosis among AD, DLB, and FTD vs CN by using multimodal MRI data (T13D, FLAIR, DTI, QSM). MUQUBIA classifier will pry on automatically determined MRI features (extracted by Freesurfer, Tracula, LPA, etc..) combined with the available clinical, neuropsychological, and biological information. The final goal is to develop and publish the MUQUBIA classifier results.